Ontology highlight
ABSTRACT:
SUBMITTER: Xue Z
PROVIDER: S-EPMC8308730 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Xue Zhaolei Z Han Qi Q Huang Pengwei P Jiang Xi X Tan Ming M Zhao Yaofeng Y Li Ning N Zhang Ran R
Pathogens (Basel, Switzerland) 20210707 7
Human noroviruses (huNoVs) cause epidemic acute gastroenteritis with significant mortality and morbidity worldwide. However, there are no commercial vaccines or antivirals against these important pathogens so far. In this study, we found that bovine colostrum (bCM) inhibited huNoV VLPs and their capsid-protruding (P) domains binding to histo-blood group antigens (HBGAs) that are huNoV receptor or attachment factors for infection, suggesting that bCM may function as a natural antiviral against hu ...[more]