Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi.

ABSTRACT: Malaria and Chagas disease, caused by Plasmodium spp. and Trypanosoma cruzi parasites, remain important global health problems. Available treatments for those diseases present several limitations, such as lack of efficacy, toxic side effects, and drug resistance. Thus, new drugs are urgently needed. The discovery of new drugs may be benefited by considering the significant biological differences between hosts and parasites. One of the most striking differences is found in the purine metabolism, because most of the parasites are incapable of de novo purine biosynthesis. Herein, we have analyzed the in vitro anti-P. falciparum and anti-T. cruzi activity of a collection of 81 purine derivatives and pyrimidine analogs. We firstly used a primary screening at three fixed concentrations (100, 10,

SUBMITTER: Martinez-Peinado N 

PROVIDER: S-EPMC8308784 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature