Light- and Melanin Nanoparticle-Induced Cytotoxicity in Metastatic Cancer Cells.

ABSTRACT: Melanin nanoparticles are known to be biologically benign to human cells for a wide range of concentrations in a high glucose culture nutrition. Here, we show cytotoxic behavior at high nanoparticle and low glucose concentrations, as well as at low nanoparticle concentration under exposure to (nonionizing) visible radiation. To study these effects in detail, we developed highly monodispersed melanin nanoparticles (both uncoated and glucose-coated). In order to study the effect of significant cellular uptake of these nanoparticles, we employed three cancer cell lines: VM-M3, A375 (derived from melanoma), and HeLa, all known to exhibit strong macrophagic character, i.e., strong nanoparticle uptake through phagocytic ingestion. Our main observations are: (i) metastatic VM-M3 cancer cells mass

SUBMITTER: Gabriele VR 

PROVIDER: S-EPMC8309021 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature