Effect of Protoberberine-Rich Fraction of Chelidonium majus L. on Endometriosis Regression.

ABSTRACT: Endometriosis is a gynecological disease defined by the presence of endometrial tissue outside the uterus. To date, the effective treatment of this disease is still based on invasive surgery or laparoscopy. Chelidonium majus L. (Papaveraceae) belongs to medicinal, latex-bearing plants. Extracts from the plant are a rich source of pharmacologically active agents. Protoberberine compounds derived from C. majus possess anticancer and antiproliferative activities. In the present study of a rat model of endometriosis, we investigated the influence of the plant protoberberine-rich fraction (BBR) obtained from the medicinal plant C. majus on the development of endometriosis. To understand of BBR therapeutic potential for endometriosis, metabolomics has been applied to study. BBR was prepared from

SUBMITTER: Warowicka A 

PROVIDER: S-EPMC8309065 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature