Thermal (In)stability of Atropine and Scopolamine in the GC-MS Inlet.

ABSTRACT: The intoxication due to unintentional or intentional ingestion of plant material containing tropane alkaloids is quite frequent. GC-MS method is still widely used for the identification of these toxicologically important substances in human specimen. During general unknown analysis, high temperature of inlet, at least 270 °C, is commonly used for less volatile substances. Unfortunately, both tropanes are thermally unstable and could be overlooked due to their degradation. The temperature-related degradation of tropanes atropine and scopolamine was systematically studied in the inlet of a GC-MS instrument in the range 110-250 °C by increments of 20 °C, additionally also at 275 °C, and in different solvents. At inlet temperatures not higher than 250 °C, the degradation products were formed b

SUBMITTER: Kozelj G 

PROVIDER: S-EPMC8309868 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature