Fitness Estimation for Viral Variants in the Context of Cellular Coinfection.

ABSTRACT: Animal models are frequently used to characterize the within-host dynamics of emerging zoonotic viruses. More recent studies have also deep-sequenced longitudinal viral samples originating from experimental challenges to gain a better understanding of how these viruses may evolve in vivo and between transmission events. These studies have often identified nucleotide variants that can replicate more efficiently within hosts and also transmit more effectively between hosts. Quantifying the degree to which a mutation impacts viral fitness within a host can improve identification of variants that are of particular epidemiological concern and our ability to anticipate viral adaptation at the population level. While methods have been developed to quantify the fitness effects of mutations using o

SUBMITTER: Zhu H 

PROVIDER: S-EPMC8310006 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature