Immune Responses to Pandemic H1N1 Influenza Virus Infection in Pigs Vaccinated with a Conserved Hemagglutinin HA1 Peptide Adjuvanted with CAF^®01 or CDA/αGalCerMPEG.

ABSTRACT: This study aimed to evaluate the immune response and protection correlates against influenza virus (IV) infection in pigs vaccinated with the novel NG34 HA1 vaccine candidate adjuvanted with either CAF^®01 or CDA/αGalCerMPEG (αGCM). Two groups of six pigs each were vaccinated intramuscularly twice with either NG34 + CAF^®01 or NG34 + CDA/αGCM. As controls, groups of animals (n = 6 or 4) either non-vaccinated or vaccinated with human seasonal trivalent influenza vaccine or NG34 + Freund's adjuvant were included in the study. All animal groups were challenged with the 2009 pandemic (pdm09) strain of H1N1 (total amount of 7 × 10⁶ TCID₅₀/mL) via intranasal and endotracheal routes 21 days after second vaccination. Reduced consolidated lung lesion

SUBMITTER: Lopez-Serrano S 

PROVIDER: S-EPMC8310093 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature