Ontology highlight
ABSTRACT:
SUBMITTER: Suraweera CD
PROVIDER: S-EPMC8310162 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Suraweera Chathura D CD Hinds Mark G MG Kvansakul Marc M
Viruses 20210715 7
Numerous viruses have evolved sophisticated countermeasures to hijack the early programmed cell death of host cells in response to infection, including the use of proteins homologous in sequence or structure to Bcl-2. Orf virus, a member of the <i>parapoxviridae</i>, encodes for the Bcl-2 homolog ORFV125, a potent inhibitor of Bcl-2-mediated apoptosis in the host. ORFV125 acts by directly engaging host proapoptotic Bcl-2 proteins including Bak and Bax as well as the BH3-only proteins Hrk and Pum ...[more]