Quaternary Interaction of the HIV-1 Envelope Trimer with CD4 and Neutralizing Antibodies.

ABSTRACT: The entry of HIV-1 into host cells is initiated by the interaction of the viral envelope (Env) spike with the CD4 receptor. During this process, the spike undergoes a series of conformational changes that eventually lead to the exposure of the fusion peptide located at the N-terminus of the transmembrane glycoprotein, gp41. Recent structural and functional studies have provided important insights into the interaction of Env with CD4 at various stages. However, a fine elucidation of the earliest events of CD4 contact and its immediate effect on the Env conformation remains a challenge for investigation. Here, we summarize the discovery of the quaternary nature of the CD4-binding site in the HIV-1 Env and the role of quaternary contact in the functional interaction with the CD4 receptor. We

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8310203 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature