Sero-Monitoring of Horses Demonstrates the Equivac^® HeV Hendra Virus Vaccine to Be Highly Effective in Inducing Neutralising Antibody Titres.

ABSTRACT: Hendra virus (HeV) is a high consequence zoonotic pathogen found in Australia. The HeV vaccine was developed for use in horses and provides a One Health solution to the prevention of human disease. By protecting horses from infection, the vaccine indirectly protects humans as well, as horses are the only known source of infection for humans. The sub-unit-based vaccine, containing recombinant HeV soluble G (sG) glycoprotein, was released by Pfizer Animal Health (now Zoetis) for use in Australia at the end of 2012. The purpose of this study was to collate post-vaccination serum neutralising antibody titres as a way of assessing how the vaccine has been performing in the field. Serum neutralization tests (SNTs) were performed on serum samples from vaccinated horses submitted to the laboratory

SUBMITTER: Halpin K 

PROVIDER: S-EPMC8310234 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature