Snapshots of a Non-Canonical RdRP in Action.

ABSTRACT: RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed "right hand" architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polymerization activity. The four palm motifs, arranged in the sequential order A to D, are common to all known template dependent polynucleotide polymerases, with motifs A and C containing the catalytic aspartic acid residues. Exceptions to this design have been reported in members of the Permutotetraviridae and Birnaviridae families of positive single stranded (+ss) and double-stranded (ds) RNA viruses, respectively. In these enzymes, motif C is located upstream of motif A, displaying a permuted C-A-B-D connectivity. Here we study the details of the re

SUBMITTER: Ferrero DS 

PROVIDER: S-EPMC8310298 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature