The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters.
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SUBMITTER: Castagna M
PROVIDER: S-EPMC8310414 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters.
Castagna Michela M Cinquetti Raffaella R Verri Tiziano T Vacca Francesca F Giovanola Matteo M Barca Amilcare A Romanazzi Tiziana T Roseti Cristina C Galli Alessandra A Bossi Elena E
Neurochemical research 20210724 1
To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating function ...[more]
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