Atomic Scale Interactions between RNA and DNA Aptamers with the TNF-α Protein.

ABSTRACT: Interest in the design and manufacture of RNA and DNA aptamers as apta-biosensors for the early diagnosis of blood infections and other inflammatory conditions has increased considerably in recent years. The practical utility of these aptamers depends on the detailed knowledge about the putative interactions with their target proteins. Therefore, understanding the aptamer-protein interactions at the atomic scale can offer significant insights into the optimal apta-biosensor design. In this study, we consider one RNA and one DNA aptamer that were previously used as apta-biosensors for detecting the infection biomarker protein TNF-α, as an example of a novel computational workflow for selecting the aptamer candidate with the highest binding strength to a target. We combine information

SUBMITTER: Asadzadeh H 

PROVIDER: S-EPMC8310448 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature