Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration.

ABSTRACT: Overactivated inflammatory responses contribute to adverse ventricular remodeling after myocardial infarction (MI). Regulatory B cells (Bregs) are a newly discovered subset of B cells with immunomodulatory roles in many immune and inflammation-related diseases. Our study aims to determine whether the expansion of Bregs exerts a beneficial effect on ventricular remodeling and explore the mechanisms involved. Here, we showed that adoptive transfer of Bregs ameliorated ventricular remodeling in a murine MI model, as demonstrated by improved cardiac function, decreased scar size and attenuated interstitial fibrosis without changing the survival rate. Reduced Ly6C^hi monocyte infiltration was found in the hearts of the Breg-transferred mice, while the infiltration of Ly6C^lo

SUBMITTER: Jiao J 

PROVIDER: S-EPMC8310480 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature