Progranulin deficiency in Iba-1⁺ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and plays an important role in controlling the lysosomal function. A deficiency in PGRN leads to inflammation of the neurons in the central nervous system. The purpose of this study was to investigate the role played by PGRN in the size of the choroidal neovascularization (CNV) in laser-induced CNV mice.

Methods

CNVs were induced in C57BL/6J mice by laser photocoagulation of the retina. The expression of PGRN and the accumulation of Iba-1⁺ cells around the sites of the CNVs

SUBMITTER: Takahashi K 

PROVIDER: S-EPMC8310601 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature