RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans.

ABSTRACT: Prostate cancer (PCa) in Black Americans (BA) is diagnosed at an earlier median age and a more advanced stage than PCa in White Americans (WA). Tumor-adjacent stroma (TAS) plays a critical role in tumorigenesis of prostate cancer. We examined RNA expression in both tumor and TAS of BA compared to WA. After evaluating the geographical ancestry of each sample, preliminary analysis of our own RNA-seq data of 7 BA and 7 WA TAS revealed 1706 downregulated and 1844 upregulated genes in BA relative to WA PCa patients (p _adj < 0.05). An assessment of published RNA-seq data of clinically matched tumor-enriched tissues from 15 BA and 30 WA patients revealed 932 upregulated and 476 downregulated genes in BA relative to WA (p _adj < 0.05). When TAS and tumor epitheli

SUBMITTER: Rahmatpanah F 

PROVIDER: S-EPMC8310667 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature