Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos.

ABSTRACT: Differentiation of sex chromosomes is thought to have evolved with cessation of recombination and subsequent loss of genes from the degenerated partner (Y and W) of sex chromosomes, which in turn leads to imbalance of gene dosage between sexes. Based on work with traditional model species, theory suggests that unequal gene copy numbers lead to the evolution of mechanisms to counter this imbalance. Dosage compensation, or at least achieving dosage balance in expression of sex-linked genes between sexes, has largely been documented in lineages with male heterogamety (XX/XY sex determination), while ZZ/ZW systems are assumed to be usually associated with the lack of chromosome-wide gene dose regulatory mechanisms. Here, we document that although the pygopodid geckos evolved male heterogamety

SUBMITTER: Rovatsos M 

PROVIDER: S-EPMC8310713 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature