Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity.

ABSTRACT:

Objective

The prevalence of obesity is growing globally. Adiposity increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease. Adipose tissue distribution influences systemic metabolism and impacts metabolic disease risk. The link between sexual dimorphisms of adiposity and metabolism is poorly defined. We hypothesise that depot-specific adipose tissue mitochondrial function contributes to the sexual dimorphism of metabolic flexibility in obesity.

Methods

Male and female mice fed high fat diet (HFD) or standard diet (STD) from 8-18 weeks of age underwent whole animal calorimetry and high-resolution mitochondrial respirometry analysis on adipose tissue depots. To determine translatability we used RT-qPCR to examine key brown adipocyte-associated gen

SUBMITTER: MacCannell ADV 

PROVIDER: S-EPMC8310795 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature