Expression of estrogen-related receptors in ovarian cancer and impact on survival.

ABSTRACT:

Purpose

This study further approaches the role of estrogen-related receptors (ERRs) in ovarian cancer. Protein expression of ERRα, ERRβ and ERRγ in ovarian cancer was assessed and was correlated with ovarian cancer markers, steroid hormone receptors and cancer-associated genes. Additionally, we examined to what extent expression of ERRs affects survival of ovarian cancer patients.

Methods

For this purpose, we established a tissue microarray from 208 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins.

Results

ERRα and ERRγ protein could be detected at different levels in more than 90% of all ovarian cancer tissues, whereas expression of ERRβ was observed in 82.2% of the cases. ERRα was found to positively correlate with ovarian

SUBMITTER: Schuler-Toprak S 

PROVIDER: S-EPMC8310835 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature