Lactobacillus acidophilus and vitamin C attenuate ethanol-induced intestinal and liver injury in mice.

ABSTRACT: Ethanol exposure frequently induces intestinal and liver injury, dysbiosis of the gut microbiota and vitamin C (VC) deficiency. Gut microbiota-targeted therapy is emerging as an important adjuvant method for protecting the body against ethanol-induced injury, particularly probiotics containing Lactobacillus acidophilus (LA). However, the feasibility and efficiency of using synbiotics containing LA and VC against ethanol-induced injury remained largely undetermined. To examine the advantages of LA+VC, their effect was evaluated in an ethanol-fed mouse model. The results suggested that LA+VC restored gut microbiota homeostasis and reinstated the immune balance of colonic T-regulatory cells (CD4⁺CD45⁺forkhead box p3⁺). In addition, intestinal barrier di

SUBMITTER: Lu X 

PROVIDER: S-EPMC8311231 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature