Advances in molecular mechanisms of pelvic organ prolapse (Review).

ABSTRACT: Pelvic organ prolapse (POP) is a common gynecological benign disease occurring in middle-aged and elderly females. Its incidence increases every year. To date, the majority of studies investigating its etiology have not evaluated the underlying molecular mechanisms, which has caused substantial difficulties in the prevention, treatment and prognosis of POP. In the present narrative review, recent research studies concerning the molecular mechanisms of POP were systematically reviewed and the advances were summarized. The association between the incidence of POP and the reduction of the extracellular matrix, activation of oxidative stress, genetic susceptibility, denervation of the pelvic floor and reduction of estrogen infiltration were explored. POP is mainly associated with damage of pel

SUBMITTER: Deng ZM 

PROVIDER: S-EPMC8311251 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature