Inflammatory Stratification in Primary Sjogren's Syndrome Reveals Novel Immune Cell Alterations in Patients' Minor Salivary Glands.

ABSTRACT: There is a critical need to deconvolute the heterogeneity displayed by the minor salivary glands of primary Sjögren's syndrome (pSS) patients. This is challenging primarily because the disease etiology remains unknown. The hypothesis includes that initial events in the disease pathogenesis target the salivary glands, thereby triggering the development of focal infiltrates (≥50 mononuclear cells) and finally germinal center-like structures. However, the proportion of key mononuclear immune cells residing at these sites, in combination with the overall ratio of morphometric tissue atrophy and adipose infiltration within the minor salivary glands (MSG) parenchyma at distinct phases of inflammatory disease establishment and progression have not been quantified in detail. In this cross-sectiona

SUBMITTER: Bharaj TK 

PROVIDER: S-EPMC8311440 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature