Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis.

ABSTRACT: Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics. A data science approach is used to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression. Computer-aided knowledge discovery for epigenetic implications of current approved or investigational drugs was performed by querying information from multiple publicly available gold-standard sources to (i) identify enzymes involved in classical epigenetic processes, (ii) screen original biomedical scientific publications including bibliometric analyses, (iii) identify drugs that interact with epigenetic enzymes, including their addi

SUBMITTER: Kringel D 

PROVIDER: S-EPMC8311652 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature