Drug repurposing strategies of relevance for Parkinson's disease.

ABSTRACT: Parkinson's disease is a highly disabling, progressive neurodegenerative disease that manifests as a mix of motor and non-motor signs. Although we are equipped with some symptomatic treatments, especially for the motor signs of the disease, there are still no established disease-modifying drugs so the disease progresses unchecked. Standard drug discovery programs for disease-modifying therapies have provided key insights into the pathogenesis of Parkinson's disease but, of the many positive candidates identified in pre-clinical studies, none has yet translated into a successful clinically efficacious drug. Given the huge cost of drug discovery programs, it is not surprising that much attention has turned toward repurposing strategies. The trialing of an established therapeutic has the adva

SUBMITTER: Fletcher EJR 

PROVIDER: S-EPMC8311732 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature