Interaction of Neighborhood and Genetic Risk on Waist Circumference in African-American Adults: A Longitudinal Study.

ABSTRACT:

Background

Understanding determinants of metabolic risk has become a national priority given the increasingly high prevalence rate of this condition among U.S. adults.

Purpose

This study's aim was to assess the impact of gene-by-neighborhood social environment interactions on waist circumference (WC) as a primary marker of metabolic risk in underserved African-American adults. Based on a dual-risk model, it was hypothesized that those with the highest genetic risk and who experienced negative neighborhood environment conditions would demonstrate higher WC than those with fewer risk factors.

Methods

This study utilized a subsample of participants from the Positive Action for Today's Health environmental intervention to improve access and safety for walking in higher-cr

SUBMITTER: McDaniel T 

PROVIDER: S-EPMC8311785 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature