Rodent Malaria Erythrocyte Preference Assessment by an Ex Vivo Tropism Assay.

ABSTRACT: Circulating red blood cells consist of young erythrocytes (early and late reticulocytes) and mature erythrocytes (normocytes). The human malaria parasites, Plasmodium falciparum and P. vivax, have a preference to invade reticulocytes during blood-stage infection. Rodent malaria parasites that also prefer reticulocytes could be useful tools to study human malaria reticulocyte invasion. However, previous tropism studies of rodent malaria are inconsistent from one another, making it difficult to compare cell preference of different parasite species and strains. In vivo measurements of cell tropism are also subjected to many confounding factors. Here we developed an ex vivo tropism assay for rodent malaria with highly purified fractions of murine reticulocytes and n

SUBMITTER: Leong YW 

PROVIDER: S-EPMC8311856 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature