Shared Pathogenetic Features Between Common Variable Immunodeficiency and Sjogren's Syndrome: Clues for a Personalized Medicine.

ABSTRACT: Common variable immunodeficiency disorders (CVID) are a group of rare diseases of the immune system and the most common symptomatic primary antibody deficiency in adults. The "variable" aspect of CVID refers to the approximately half of the patients who develop non-infective complications, mainly autoimmune features, in particular organ specific autoimmune diseases including thyroiditis, and cytopenias. Among these associated conditions, the incidence of lymphoma, including mucosal associated lymphoid tissue (MALT) type, is increased. Although these associated autoimmune disorders in CVID are generally attributed to Systemic Lupus Erythematosus (SLE), we propose that Sjogren's syndrome (SS) is perhaps a better candidate for the associated disease. SS is an autoimmune disorder characterized

SUBMITTER: Quartuccio L 

PROVIDER: S-EPMC8311857 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature