Selective Functional Network Changes Following tDCS-Augmented Language Treatment in Primary Progressive Aphasia.

ABSTRACT:

Objective

Transcranial direct current stimulation (tDCS) has shown promising results when used as an adjunct to behavioral training in neurodegenerative diseases. However, the underlying neural mechanisms are not understood and neuroimaging evidence from pre/post treatment has been sparse. In this study, we examined tDCS-induced neural changes in a language intervention study for primary progressive aphasia (PPA), a neurodegenerative syndrome with language impairment as the primary clinical presentation. Anodal tDCS was applied to the left inferior frontal gyrus (LIFG). To evaluate the hypothesis that tDCS promotes system segregation, analysis focused on understanding tDCS-induced changes in the brain-wide functional network connectivity of the targeted LIFG.

Methods

Resting

SUBMITTER: Tao Y 

PROVIDER: S-EPMC8311858 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature