Bisphenol A Activates an Innate Viral Immune Response Pathway.

ABSTRACT: Bisphenol A (BPA) is a ubiquitous component in the manufacturing of plastic. It is commonly found in food and beverage containers. Because of its broad exposure and evidence that it may act as an estrogen-like molecule, many have studied its potential effects. For example, epidemiological studies have found an association between in utero BPA exposure and onset of childhood asthma. Our previous work suggested BPA treated mice induced asthma-like symptoms in both mothers and their pups. In order to better understand theconsequences of BPA exposure and potential mechanisms, we used a proteomics approach. Using both CD4⁺ T cells from an in vivo model of BPA exposure and an in vitro epithelial cell model, we identified activation of both innate and adaptive immune signaling followin

SUBMITTER: Sowers ML 

PROVIDER: S-EPMC8311900 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature