Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase.

ABSTRACT: Mitochondrial F-type adenosine triphosphate (ATP) synthases are commonly introduced as highly conserved membrane-embedded rotary machines generating the majority of cellular ATP. This simplified view neglects recently revealed striking compositional diversity of the enzyme and the fact that in specific life stages of some parasites, the physiological role of the enzyme is to maintain the mitochondrial membrane potential at the expense of ATP rather than to produce ATP. In addition, mitochondrial ATP synthases contribute indirectly to the organelle's other functions because they belong to major determinants of submitochondrial morphology. Here, we review current knowledge about the trypanosomal ATP synthase composition and architecture in the context of recent advances in the structural cha

SUBMITTER: Gahura O 

PROVIDER: S-EPMC8311965 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature