Genome-Wide Association Study (GWAS) of dental caries in diverse populations.

ABSTRACT:

Background

Dental caries is one of the most common chronic diseases and is influenced by a complex interplay of genetic and environmental factors. Most previous genetic studies of caries have focused on identifying genes that contribute to dental caries in specific ethnic groups, usually of European descent.

Methods

The aim of this study is to conduct a genome-wide association study (GWAS) to identify associations affecting susceptibility to caries in a large multiethnic population from Argentina, the Philippines, Guatemala, Hungary, and the USA, originally recruited for studies of orofacial clefts (POFC, N = 3686). Ages of the participants ranged from 2 to 12 years for analysis of the primary dentition, and 18-60 years for analysis of the permanent dentition. For each parti

SUBMITTER: Alotaibi RN 

PROVIDER: S-EPMC8311973 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature