Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies.

ABSTRACT: Influenza viruses pose a significant threat to the public and are a burden on global health systems. Each year, influenza vaccines must be rapidly produced to match circulating viruses, a process constrained by dated technology and vulnerable to unexpected strains emerging from humans and animal reservoirs. Here we use knowledge of protein structure to design self-assembling nanoparticles that elicit broader and more potent immunity than traditional influenza vaccines. The viral haemagglutinin was genetically fused to ferritin, a protein that naturally forms nanoparticles composed of 24 identical polypeptides. Haemagglutinin was inserted at the interface of adjacent subunits so that it spontaneously assembled and generated eight trimeric viral spikes on its surface. Immunization with this

SUBMITTER: Kanekiyo M 

PROVIDER: S-EPMC8312026 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature