Results of the association study of the type 3 matrix metalloproteinase gene - 1171 5A/6A (rs35068180) and dilated cardiomyopathy

ABSTRACT: Abstract

Funding Acknowledgements

Type of funding sources: Public Institution(s). Main funding source(s): Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Background

Remarkable progress has been made in understanding the genetic basis of dilated cardiomyopathy (DCM). Rare variants in >30 genes, some also involved in other cardiomyopathies, muscular dystrophy, or syndromic disease, perturb a diverse set of important myocardial proteins to produce a final DCM phenotype.

Research objective

The purpose of the present study was to determine the association between matrix metalloproteinase -3 (MMP-3) gene polymorphism - 1171 5A/6A (rs35068180) with myocardial dilation of ischemic and idiopathic origin.

Materials and methods

We studied 221 patie

SUBMITTER: Nikulina S 

PROVIDER: S-EPMC8312071 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature