A <i>Trypanosoma cruzi</i> zinc finger protein that is implicated in the control of epimastigote-specific gene expression and metacyclogenesis.

ABSTRACT: Trypanosoma cruzi has three biochemically and morphologically distinct developmental stages that are programmed to rapidly respond to environmental changes the parasite faces during its life cycle. Unlike other eukaryotes, Trypanosomatid genomes contain protein coding genes that are transcribed into polycistronic pre-mRNAs and have their expression controlled by post-transcriptional mechanisms. Transcriptome analyses comparing three stages of the T. cruzi life cycle revealed changes in gene expression that reflect the parasite adaptation to distinct environments. Several genes encoding RNA binding proteins (RBPs), known to act as key post-transcriptional regulatory factors, were also differentially expressed. We characterized one T. cruzi RBP, named TcZH3H12, which contains a zinc finger d

SUBMITTER: Tavares TS 

PROVIDER: S-EPMC8312218 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature