Anti-Microbiota Vaccines Modulate the Tick Microbiome in a Taxon-Specific Manner.

ABSTRACT: The lack of tools for the precise manipulation of the tick microbiome is currently a major limitation to achieve mechanistic insights into the tick microbiome. Anti-tick microbiota vaccines targeting keystone bacteria of the tick microbiota alter tick feeding, but their impact on the taxonomic and functional profiles of the tick microbiome has not been tested. In this study, we immunized a vertebrate host model (Mus musculus) with live bacteria vaccines targeting keystone (i.e., Escherichia-Shigella) or non-keystone (i.e., Leuconostoc) taxa of tick microbiota and tested the impact of bacterial-specific antibodies (Abs) on the structure and function of tick microbiota. We also investigated the effect of these anti-microbiota vaccines on mice gut microbiota composition.

SUBMITTER: Mateos-Hernandez L 

PROVIDER: S-EPMC8312226 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature