Galectin-3 and Estrogen Receptor Alpha as Prognostic Markers in Prolactinoma: Preliminary Results From a Pilot Study.

ABSTRACT:

Introduction

Prolactin-secreting pituitary tumors (PRL-omas) are generally benign neoplasia. However, a percentage of cases show aggressive behavior. Prognostic markers may allow for the identification of aggressive cases. In this study, we investigated the prognostic role of galectin-3 and the estrogen receptor alpha (ERα), as predictive biomarkers of aggressiveness and poor prognosis.

Patients and methods

A mono-centric and retrospective study was conducted on consecutive cases of PRL-omas that underwent first line treatment with surgery and were followed-up for at least five years. The immunohistochemical expression of ERα and galectin-3 was investigated in each case.

Results

36 patients were enrolled. Galectin-3 resulted positive in 11 patients (30.6%). The median

SUBMITTER: Bima C 

PROVIDER: S-EPMC8312245 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature