Establishment and Validation of a Comprehensive Prognostic Model for Patients With HNSCC Metastasis.

ABSTRACT:

Objective

To identify biomarkers related to head and neck squamous cell carcinoma (HNSCC) metastasis and establish a prognostic model for patients with HNSCC.

Methods

HNSCC mRNA expression data of metastasis and non-metastatic samples were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. After screening the differentially expressed genes (DEGs) in the two datasets, a prognostic model, including clinical factors and biomarkers, was established, and verified in 36 samples of HNSCC by quantitative real-time transcription (qRT)-PCR. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene sets enrichment analysis (GSEA) were consulted to explore the functions of the DEGs.

Results

In total, 108 DEGs were identi

SUBMITTER: Shen Y 

PROVIDER: S-EPMC8312248 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature