Attention shifting in the context of emotional faces: Disentangling neural mechanisms of irritability from anxiety.

ABSTRACT:

Background

Irritability predicts concurrent and prospective psychiatric disorders across the lifespan. Anxiety commonly co-occurs with irritability, and such comorbidity complicates care. Understanding the mechanisms of comorbid traits is necessary to inform treatment decisions. This study aimed to disentangle neural mechanisms of irritability from anxiety in the context of attentional shifting toward and away from emotional faces in youths from treatment-seeking families.

Methods

Youths (N = 45), mean age = 14.01 years (standard deviation = 1.89) completed a dot-probe task during functional magnetic resonance imaging acquisition. Whole-brain activation analyses evaluated the effect of irritability on neural reactivity in the context of varying attentional shifting toward an

SUBMITTER: Kryza-Lacombe M 

PROVIDER: S-EPMC8312255 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature