Effect of single nanoparticle-nanopore interaction strength on ionic current modulation.

ABSTRACT: Solid-state nanopores are rapidly emerging as promising platforms for developing various single molecule sensing applications. The modulation of ionic current through the pore due to translocation of the target molecule has been the dominant measurement modality in nanopore sensors. Here, we focus on the dwell time, which is the duration taken by the target molecule or particle to traverse the pore and study its dependence on the strength of interaction of the target with the pore using single gold nanoparticles (NPs) as targets interacting with a silicon nitride (SiN) nanopore. The strength of interaction, which in our case is electrostatic in nature, can be controlled by coating the nanoparticles with charged polymers. We report on an operating regime of this nanopore sensor, characteriz

SUBMITTER: Pal S 

PROVIDER: S-EPMC8312308 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature