Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common type of brain cancer with poor survival outcomes and unsatisfactory response to current therapeutic strategies. Recent studies have demonstrated that ferroptosis-related genes (FRGs) are linked with the occurrence and development of GBM and may become promising biological indicators in GBM therapy.

Methods

We systematically assessed the relationship between FRGs expression profiles and prognosis in glioma patients based on the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) datasets to establish a risk score model according to the gene signature of multiple survival-associated DEGs. Further, the differences between the tumor microenvironment score, immune cell infiltration, immune checkpoint expression levels

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8312442 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature