Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis.

ABSTRACT:

Background and purpose

Metabolic traits affect ischemic stroke (IS) risk, but the degree to which this varies across different ethnic ancestries is not known. Our aim was to apply Mendelian randomization to investigate the causal effects of type 2 diabetes (T2D) liability and lipid traits on IS risk in African ancestry individuals, and to compare them to estimates obtained in European ancestry individuals.

Methods

For African ancestry individuals, genetic proxies for T2D liability and circulating lipids were obtained from a meta-analysis of the African Partnership for Chronic Disease Research study, the UK Biobank, and the Million Veteran Program (total N=77 061). Genetic association estimates for IS risk were obtained from the Consortium of Minority Population Genome-Wide A

SUBMITTER: Fatumo S 

PROVIDER: S-EPMC8312569 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature