MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes.

ABSTRACT:

Objective

Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. We sought to: (1) evaluate radiomics to assess brain structural integrity by predicting white matter hyperintensities burdens (WMH) and (2) uncover associations between predictive radiomic features and clinical phenotypes.

Methods

We analyzed a multi-site cohort of 4,163 acute ischemic strokes (AIS) patients with T2-FLAIR MR images with total brain and WMH segmentations. Radiomic features were extracted from normal-appearing brain tissue (brain mask-WMH mask). Radiomics-based

SUBMITTER: Bretzner M 

PROVIDER: S-EPMC8312571 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature