Analyses of publicly available Hungatella hathewayi genomes revealed genetic distances indicating they belong to more than one species.

ABSTRACT: Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological prospective to cause disease. In this study, a patient with chronic neurologic symptoms presented to the clinic with subsequent isolation of a strain with phenotypic characteristics suggestive of Clostridium difficile. However, whole-genome sequence found the organism to be H. hathewayi. Analysis including publicly available Hungatella genomes found substantial genomic differences as compared to the type strain, indicating this isolate was not C. difficile. We examined the whole-genome of Hungatella sp

SUBMITTER: Hernandez-Juarez LE 

PROVIDER: S-EPMC8312603 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature