Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease.

ABSTRACT:

Objective

Dyslipidemia is a significant risk factor for progression of diabetic kidney disease (DKD). Determining the changes in individual lipids and lipid networks across a spectrum of DKD severity may identify lipids that are pathogenic to DKD progression.

Methods

We performed untargeted lipidomic analysis of kidney cortex tissue from diabetic db/db and db/db eNOS^-/- mice along with non-diabetic littermate controls. A subset of mice were treated with the renin-angiotensin system (RAS) inhibitors, lisinopril and losartan, which improves the DKD phenotype in the db/db eNOS^-/- mouse model.

Results

Of the three independent variables in this study, diabetes had the largest impact on overall lipid levels in the kidney cortex, while eNOS expression a

SUBMITTER: Sas KM 

PROVIDER: S-EPMC8312633 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature