The abaI/abaR Quorum Sensing System Effects on Pathogenicity in Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is a Gram-negative pathogen that has emerged as one of the most troublesome pathogens for healthcare institutions globally. Bacterial quorum sensing (QS) is a process of cell-to-cell communication that relies on the production, secretion, and detection of autoinducer (AI) signals to share information about cell density and regulate gene expression accordingly. The molecular and genetic bases of A. baumannii virulence remains poorly understood. Therefore, the contribution of the abaI/abaR QS system to growth characteristics, morphology, biofilm formation, resistance, motility, and virulence of A. baumannii was studied in detail. RNA sequencing (RNA-seq) analysis indicated that genes involved in various aspects of energy production a

SUBMITTER: Sun X 

PROVIDER: S-EPMC8312687 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature