Epigenetic Regulation in Sepsis, Role in Pathophysiology and Therapeutic Perspective.

ABSTRACT: Sepsis is characterized by an initial hyperinflammatory response, with intense cell activation and cytokine storm. In parallel, a prolonged compensatory anti-inflammatory response, known as immunological tolerance, can lead to immunosuppression. Clinically, this condition is associated with multiple organ failure, resulting in the patient's death. The mechanisms underlying the pathophysiology of sepsis are not yet fully understood, but evidence is strong showing that epigenetic changes, including DNA methylation and post-translational modifications of histones, modulate the inflammatory response of sepsis. During the onset of infection, host cells undergo epigenetic changes that favor pathogen survival. Besides, epigenetic changes in essential genes also orchestrate the patient's inflammat

SUBMITTER: Falcao-Holanda RB 

PROVIDER: S-EPMC8312749 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature