QS7: Digit Tip Regeneration Following Amputation Is Not True Regeneration

ABSTRACT:

Purpose:

Repair of distal phalanx amputation is widely studied and thought to occur through a regenerative process. Single-cell RNA sequencing (scRNA) has greatly improved the ability to characterize the cells that are involved in regeneration and abnormal healing of bone and soft tissue. Given the disorganized architecture of digit tip “regenerated” bone and its common progenitor cell to the pathologic process of heterotopic ossification, we hypothesized that digit tip repair after injury follows a program of aberrant wound repair rather than true regeneration of normal bone tissue.

Methods:

ScRNA data of mouse digit tip amputation (DTA) and embryonic limb development (EMB) was downloaded from NBCI GEO data base ascension number GSE135985. Additionally, scRNA data from h

SUBMITTER: Pagani C 

PROVIDER: S-EPMC8312837 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature