Urinary actin, as a potential marker of sepsis-related acute kidney injury: A pilot study.

ABSTRACT:

Introduction

A major complication of sepsis is the development of acute kidney injury (AKI). Recently, it was shown that intracellular actin released from damaged tissues appears in the urine of patients with multiple organ dysfunction syndrome. Our aims were to measure urinary actin (u-actin) concentrations of septic and control patients and to test if u-actin levels could predict AKI and mortality.

Methods

Blood and urine samples were collected from septic and sepsis-related AKI patients at three time points (T1-3): T1: within 24 hours after admission; T2: second day morning; T3: third day morning of follow-up. Patients with malignancies needing palliative care, end-stage renal disease or kidney transplantation were excluded. Serum and u-actin levels were determined by qua

SUBMITTER: Ragan D 

PROVIDER: S-EPMC8312921 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature