The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells.

ABSTRACT: Iron and other transition metals, such as copper and manganese, are essential for supporting brain function, yet over-accumulation is cytotoxic. This over-accumulation of metals, particularly iron, is common to several neurological disorders; these include Alzheimer's disease, Parkinson's disease, Friedrich's ataxia and other disorders presenting with neurodegeneration and associated brain iron accumulation. The management of iron flux by the blood-brain barrier provides the first line of defense against the over-accumulation of iron in normal physiology and in these pathological conditions. In this study, we determined that the iron chelator PBT434, which is currently being developed for treatment of Parkinson's disease and multiple system atrophy, modulates the uptake of iron by human br

SUBMITTER: Bailey DK 

PROVIDER: S-EPMC8312958 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature