Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section.

ABSTRACT:

Background

Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD) degeneration and regeneration. IVD morphology is commonly assessed using histology, which forms the foundation for quantifying the state of IVD degeneration. IVD degeneration severity is evaluated using different grading systems that focus on distinct degenerative features. A standard grading system would facilitate more accurate comparison across laboratories and more robust comparisons of different models and interventions.

Aims

This study aimed to develop a histology grading system to quantify IVD degeneration for different rat models.

Materials & methods

This study involved a literature review, a survey of experts in the field, and a validation study using 25 slides th

SUBMITTER: Lai A 

PROVIDER: S-EPMC8313153 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature